Vertical transmission of hepatitis C from pregnant - mothers to their offsprings


Maryam Yazdani 1 , * , Saeid Shakeri 2

1 Assistant Professor, Department of Obstetric & Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Assistant Professor, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.

How to Cite: Yazdani M, Shakeri S. Vertical transmission of hepatitis C from pregnant - mothers to their offsprings, Hormozgan Med J. 2006 ; 10(2):e89806.


Hormozgan Medical Journal: 10 (2); e89806
Published Online: July 05, 2006
Article Type: Research Article
Received: February 22, 2005
Accepted: July 05, 2006




Introduction: Besides from dermal route, recently vertical transmission of
hepatitis C has been a matter of investigation and the risk of transmission is
evaluated. The aim of this study was to determine the risk of mother-to-infant
vertical transmission of hepatitis C.
Methods: In this descriptive study, over a period of 2 years, between Aug. 1998
and Jun. 2000, two thousands pregnant women were examined in the obstetric
department of Shiraz University of Medical Sciences. The patients underwent
serologic study to screen the presence of antibody to hepatitic C, hepatitis B and
HIV infection.
Clinicolabaratory tests were also scheduled for offsprings of HCV-Ab positive
mothers at birth, 6 and 12 months later. Results were presented using descriptive
Results: Twelve (0.6%) of the 2000 women were found to be positive for HCV
antibody. In two (16%) of them, positive history of jaundice was recognized, 3
(25%) patients had positive history of hepatitis in their families, 2 (16%) patients
had blood transfusion, 4 (33%) patients had dental procedures and 2 (16%)
patients had history of major operation in the previous years. Serologic screening
tests for antibodies to HIV and hepatitis B surface antigen were negative. All of
12 women had normal liver function test during pregnancy and after delivery, the
offsprings of these anti-HCV positive mothers were screened for HCV infection
at birth and 6 and 12 months after birth. All of babies were positive for HCV
antibody at birth but became negative at 6 and 12 months of age. Liver function
tests were within normal range during this period.
Conclusion: Vertical transmission of hepatitis C is uncommon and anti-HCV
antibody is most likely to be acquired passively in uterus and is eliminated by the
age 6 months. No endogenous anti-HCV antibody production was detected at 12
months of age.


Hepatitis C – Pregnancy – Metranal – Fetal – Exchange

© 2006, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.



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