Langerhans’cell histiocytosis in childhood: A case report

AUTHORS

Shahrokh Rajaei 1 , * , Amir Reza Hosseini 2 , Shahram Baghestani 3

1 Assistant Professor, Department of Pediatrics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Resident of Pediatrics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Assistant Professor Department of Internal Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Rajaei S, Hosseini A R, Baghestani S. Langerhans’cell histiocytosis in childhood: A case report, Hormozgan Med J. 2006 ; 10(2):e89892.

ARTICLE INFORMATION

Hormozgan Medical Journal: 10 (2); e89892
Published Online: September 23, 2005
Article Type: Case Report
Received: February 02, 2005
Accepted: September 23, 2005

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Abstract

Introduction: The childhood histiocytoses are a grouped of rare disorders in
which they have in common a prominent accumulation of cells of the monocytemacrophage
system of bone marrow origin.
Three classes of disease are recognized. Some of them have benign and others
malignant courses. They have variable presentations rangin from a solitary lesion
of bone to a multisystem disorder. Skeleton is the most common system involved.
Tissue biopsy is diagnostic and after that a thorough clinical and laboratory
evaluation should be undertaken. In single system disease,treatment is generally
curettage or local radiation while chemotherapy is used for multisystem
involvement.
Case report: We present a 2-years-old boy from Qeshm island with chief
complaint of skin lesions. The parents had noticed a bony defect in right frontal
10 months prior to admission, but as they thought it is due to blunt trauma, they
didn’t seek medical care.
Conclusion: The diagnosis is based on tissue biopsy and then complete clinical
and laboratory investigations. Young age and multisystem involvement have poor
prognosis.

Keywords

Histiocytosis -Langerhans Cell - Child

© 2006, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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