Effect of clofibrate plus phototherapy on bilirubin concentration of healthy full-term jaundiced neonates

AUTHORS

yadollah Zahed Pasha 1 , Salma Naderi 2 , * , Mousa Ahmadpour 3

1 Associate Professor Department of Pediatrics, Babol University of Medical Sciences, Babol, Iran.

2 Assistant Professor Department of Pediatrics, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Assistant Professor Department of Pediatrics, Babol University of Medical Sciences, Babol, Iran.

How to Cite: Zahed Pasha Y, Naderi S, Ahmadpour M. Effect of clofibrate plus phototherapy on bilirubin concentration of healthy full-term jaundiced neonates, Hormozgan Med J. 2006 ; 10(3):e90048.

ARTICLE INFORMATION

Hormozgan Medical Journal: 10 (3); e90048
Published Online: November 12, 2006
Article Type: Research Article
Received: February 06, 2006
Accepted: November 12, 2006

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Abstract

Introduction: Jaundice is one of the most common clinical sign in the neonatal
period which in severe form leads to neurotoxicity (kernicterus). This study was
carried out to determine the effect of clofibrate on serum bilirubin concentration
in icteric otherwise healthy term newborns.
Methods: The study was a double blinded, clinical trial in neonatal ward of
Shafizadeh pediatric hospital in Babol, Iran. We selected healthy full terms
breastfed infants with a birth weight of ≥2500gr and total bilirubin of ≥15mg/dl
from second day of life. Infants with hemolytic disease, need for exchange
transfusion and those treated with Phenobarbital were excluded. Newborn babies
were divided to two groups (30 cases, 30 controls). All of them received
phototherapy and case group was treated with a single oral dose of clofibrate
(100mg/kg). The bilirubin concentration was checked at 16 and 24 hours after
treatment and every 24 hours apart. Data (collected by a questionnaire including
sex, age and bilirubin concentration) were analyzed by SPSS software, statistical
t-test and fisher’s exact test.
Results: The mean plasma total bilirubin concentration at 48 hours and 72 hours
after treatment was more lower in the case group than the control group (P=0.047
and P=0.024 respectively). At the end of 72 hours, the number of discharged
neonates were higher in the case group as compared with the control group (83.3%
and 53.3% respectively with P=0.025). No side effect was observed.
Conclusion: Clofibrate leads to faster decline in indirect bilirubin concentration
and sooner discharge.

Keywords

Bilirubin – Clofibrate – Jaundice Neonatal

© 2006, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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