Comparison of hemodynamic changes of Propofol and Thiopental during induction of anesthesia and tracheal intubation

AUTHORS

Hashem Jarineshin 1 , * , Masoumeh Razmpour 2

1 Assistant Professor Department of Surgery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 General Practitioner, Hormozgan University of Medical Sciences, Bandar Abas, Iran.

How to Cite: Jarineshin H, Razmpour M. Comparison of hemodynamic changes of Propofol and Thiopental during induction of anesthesia and tracheal intubation, Hormozgan Med J. 2006 ; 10(3):e90054.

ARTICLE INFORMATION

Hormozgan Medical Journal: 10 (3); e90054
Published Online: August 13, 2006
Article Type: Research Article
Received: December 17, 2005
Accepted: August 13, 2006

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Abstract

Introduction: General anesthesia is the most common technique for performance
of various surgical procedures. Thiopental is the most common anesthetic agent
for intravenous induction. Since the introduction of propofol as an anesthetic
agent, its use has increased progressively and has become the drug of choice for
induction of anesthesia in several conditions.
The aims of this study were comparison of hemodynamic changes of propofol and
thiopental during induction of anesthesia and tracheal intubation and using
propofol instead of thiopental for induction of anesthesia.
Methods: In this double-blinded, randomized clinical trial study, 60 adult
patients in ASA class I and II (candidates for elective operation under general
anesthesia) were randomly divided in two equal groups (1. propofol, 2.
thiopental). After baseline measurment of systolic and diastolic blood pressures
and heart rate and giving similar premedication with morphine and midazolam, 1st
group received propofol (2mg/kg) and 2nd group received thiopental (5mg/kg) for
induction of anesthesia. Then systolic and diastolic blood pressures and heart rate
of patients were measured in 4 different periods: after induction of anesthesia and
before laryngoscopy and tracheal intubation, immediately after tracheal
intubation, 3 and 5 minutes after tracheal intubation. Duration of laryngoscopy
and tracheal intubation were also recorded in all patients. Data were collected and
t-test statistical analysis was done.
Results: The two groups were similar regarding age, sex, duration of
laryngoscopy and baseline hemodynamic parameters. Baseline mean systolic and
diastolic blood pressures and heart rate were also similar in both groups, but
systolic and diastolic blood pressures and heart rate measured at times after
induction of anesthesia and before laryngoscopy, immediately and 3 minutes after
tracheal intubation were significantly lower in propofol than thiopental group
(P<0.05). There were no significant differences between 2 groups at time 5
minutes after tracheal intubation.
Conclusion: According to these findings, propofol can be an ideal substitution
for thiopental as an induction agent due to stronger suppression of hemodynamic
responses to larynfoscopy and intubation.

Keywords

Propofol – Thiopental –Anesthesia General – Intubation Intratracheal

© 2006, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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