Epidemiologic study of 40 patients with lupus nephritis in Imam Khomeini hospital, Tehran

AUTHORS

Alireza Ebadi 1 , * , Batool Zamani 2 , Alireza Soleimani 1 , Mohammadreza Tamadon 3 , Mohsen Arbabi 4

1 Assistant Professor Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran.

2 Assistant Professor Department of Internal Medicine, Kashan University of Medical Sciences, kashan, Iran.

3 Assistant Professor Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran.

4 Instructor Department of Parasitology, Kashan University of Medical Sciences, Kashan, Iran.

How to Cite: Ebadi A, Zamani B, Soleimani A, Tamadon M, Arbabi M. Epidemiologic study of 40 patients with lupus nephritis in Imam Khomeini hospital, Tehran, Hormozgan Med J. 2006 ; 10(3):e90058.

ARTICLE INFORMATION

Hormozgan Medical Journal: 10 (3); e90058
Published Online: July 05, 2006
Article Type: Research Article
Received: August 01, 2005
Accepted: July 05, 2006

Crossmark

CHEKING

READ FULL TEXT
Abstract

Introduction: Systemic lupus erythematosus (SLE) is an inflammatory systemic
disease that involves different organs such as heart, lungs, hematologic and
musculoskletal systems, gastrointestinal tract and kidneys. Renal involvement has
specific importance in disease prognosis. The present study was conducted to
identify epidemiologic status, short term effects of treatment on renal
involvement, levels of complement and Anti-ds DNA in patients with lupus
nephritis admitted to Imam Khomein hospital, Tehran.
Methods: This descriptive study was conducted on 40 patients with lupus
nephritis in internal and nephrology wards of hospital. Of these patients, 37 had
documented disease. All patients had renal biopsy and had received treatment
according to their pathology reports. Data including age, gender, clinical
manifestation and pathologic findings were recorded. Results were reported in
descriptive statistics and frequency distribution tables.
Results: The patients had an average age of 12-45 years with mean age of 21.5.
The most frequency was in second decade of life (48.6%). 87.5 percent of
patients were female and 13.5 percent were male. Malar rash (62.5%) and fever
(57.7%) were the most prevalent clinical manifestations. The most frequent
pathology and sign were type IV lupus nephritis (37.8%) and hematuria (88.9%).
Based on pathology, 97 percent of patients had renal involvement. Pulse therapy
with corticosteroids and cyclophosphamide wase effective against preventing
chronic renal failure in 50% of type IV cases. 100 percent of patients with lupus
nephritis type III had bad prognosis.
Conclusion: In patients with lupus nephritis, the most prevalent clinical findings
were fever and malar rash of face, the most common renal involvement was
hematuria and the most frequent pathology was type IV lupus nephritis. Renal
involvement and prognosis is correlated with anti ds DNA titer. Types III and IV
of lupus nephritis have indication for glucocorticoids and cyclophosphamide pulse
therapy which can be preventive for chronic renal failure in 50% of cases.

Keywords

Nephritis – Lupus Nephritis – Lupus Erythematosus Systemic – Epidemiologic Studies

© 2006, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

References

  • 1.

    References are included in the PDF.

  • COMMENTS

    LEAVE A COMMENT HERE: