Electrodiagnostic study of peripheral nervous system in Behcet’s disease


Seyed Mostafa Jazayeri Shooshtari 1 , * , Kambiz Khamooshian 2 , Elham Aflaki 3

1 Associate Professor Department of Physical Medicine & Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Assistant Professor Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Assistant Professor Department of Physical Medicine & Rehabilitation, Kermanshah University of Medical Sciences, Kermanshah, Iran.

How to Cite: Jazayeri Shooshtari S M, Khamooshian K, Aflaki E. Electrodiagnostic study of peripheral nervous system in Behcet’s disease, Hormozgan Med J. 2007 ; 10(4):e90151.


Hormozgan Medical Journal: 10 (4); e90151
Published Online: October 19, 2006
Article Type: Research Article
Received: January 26, 2005
Accepted: October 19, 2006




Introduction: Bechcet’s disease (BD) is a chronic disease with multiple organ
involvement such as central nervous system (CNS) and peripheral nervous system
(PNS). Involvement of PNS has been reported controversially and uncommon in
textbooks and literatures. The aim of this study in to evaluate the auxiliary role of
electrodiagnosis in early detection of PNS involvement to prevent neuropathy in
Behcet’s disease.
Methods: This case-control survey included 40 patients with BD and 40 (control)
healthy individuals. Inclusion criteria was lack of any disease and no history of
contact with probable causative agent for neuropathy. We studied distal latency (DL),
nerve conduction velocity (NCV) and amplitude (Amp) of median, ulnar, tibial, deep
peroneal, superficial peroneal and sural nerves; also we studied GS H-Reflex of tibial
nerve and F-wave of ulnar and tibial nerves. T-test was used for data analysis.
Results: We found reduced sensory nerve action potentials (SNAP) amplitude of
ulnar, median, sural and superficial peroneal nerves comparing to control group
(P<0.05). High prevalence of entrapment neuropathy in median (carpal tunnel
syndrome) and ulnar (cubital tunnel syndrome) nerves in these patients were 35%
and 25% respectively, which is among normal range and had no statistically
significant difference with the control group.
Conclusion: These findings suggest that patients with Bechet’s vasculitis undergo
electrodiagnosis before and after treatment with neurotoxic drugs for prevention and
early detection of peripheral neuropathy. We recommend that neurotoxic drugs such
as colchicine, thalidomide and dapsone should not be, if possible, prescribed in BD,
because these patients are prone to sensory and entrapment neuropathies.


Bechcet’s Syndrome - Electro diagnosis – Peripheral Nervous System

© 2007, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.



  • 1.

    References are included in the PDF.