Bone mineral density evaluation in patients with urolithiasis


Abdolrasoul Mehrsai 1 , Hooman Jaladat 2 , * , Elham Hashemian Naiini 3 , Keramat Nourijeliani 4 , Gholamreza Pourmand 5

1 Associate Professor, Tehran University of Medical Sciences, Tehran, Iran.

2 Assistant Professor Department of Surgery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 General Practitioner, Tehran University of Medical Sciences, Tehran, Iran.

4 Assistant Professor Department of Health, Tehran University of Medical Sciences, Tehran, Iran.

5 Full Professor, Department of Urology, Tehran University of Medical Sciences, Tehran, Iran.

How to Cite: Mehrsai A, Jaladat H, Hashemian Naiini E, Nourijeliani K, Pourmand G. Bone mineral density evaluation in patients with urolithiasis, Hormozgan Med J. 2005 ; 9(3):e90373.


Hormozgan Medical Journal: 9 (3); e90373
Published Online: November 01, 2005
Article Type: Research Article
Received: December 14, 2004
Accepted: October 01, 2005




Introduction: Osteopenia of trabecular-rich bone tissues in patients with
urolithiasis has been suggested. We performed a study to evaluate the prevalence
of osteopenia and osteoporosis in Iranian patients with recurrent urinary tract
Methods: In this case control study 24 male patients, aged 30-50 years old, who
had recurrent urolithiasis (more than once per year) and were referred to
extracorporeal shock wave lithotripsy (ESWL) unit, entered our study. We also
valuated 24 healthy male controls of a comparable age group. Both groups had
similar diets.
Ages, body mass index (weight/height2), stone disease duration and BMD of two
ports, Lumbar spine (L2-L4) and femur region were evaluated and compared in
both groups. Linear, regression and t-test were used to analyze the data.
Results: Excluding confounding factors, BMD difference in both lumbar and
femur region between patients and controls were statistically significant
(P<0.01). BMD results were quite independent of age and body mass index.
According to regression analysis, there was a significant correlation between
BMD of lumbar and duration of urolithiasis (P<0.001, r=-0.73). The same
significant correlation existed between BMD of femur and duration of disease,
although not as the previous one (P<0.01, r=-0.52).
Conclusion: BMD decrease in patients with urolithiasis may herald a primary
defect of bone metabolism. As 30% of patients were osteopenic, calcium intake
and its restriction should be monitored in these patients.


Osteoporosis – Urine – Calculi – Bone Density

© 2005, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.



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