Evaluation of 2-hour and random urine samples in diagnosis of proteinuria in pregnant women

AUTHORS

Seyedeh Raziyeh Hashemi 1 , Seyedeh Zahra Bakhshoori 2 , Minoo Rajaei 2 , * , Shahram Zare 3

1 Resident, Departments of Obstetric & Gynecology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

2 Assistant Professor, Departments of Obstetric & Gynecology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Assistant Professor, Department of Community Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

How to Cite: Hashemi S R, Bakhshoori S Z, Rajaei M, Zare S . Evaluation of 2-hour and random urine samples in diagnosis of proteinuria in pregnant women, Hormozgan Med J. 2005 ; 9(3):e90376.

ARTICLE INFORMATION

Hormozgan Medical Journal: 9 (3); e90376
Published Online: July 06, 2005
Article Type: Research Article
Received: May 08, 2005
Accepted: July 06, 2005

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Abstract

Introduction: Hypertensive disorders in are common pregnancy. Combination of
hypertension and proteinuria such as preeclampsia during pregnancy markedly
increases the risk of prenatal mortality and morbidity. Inspire of numerous
studies to find a faster test for assessment of proteinuria, 24-hour urine collection
is the gold standard.
The purpose of this study was to determine whether a 2-hour protein estimation
and random urine sample correlated with that of a formal 24-hour collection.
Methods: In this the study population included 32 pregnant women over 20
weeks gestations who were admitted for assessment of proteinuria and ruling out
of preeclampsia in Dr Ali Shariati Hospital, Bandar Abbas.
Patient’s urine was collected with the first random urine sample, next 2 hour
sample and 24 hour sample. Urinary estimation of proteinuria was made on these
samples. 2-hour value was multiplied by 12 and compared with 24-hour protein.
Correlation coefficient between 2-hour and 24-hour samples, sensitivity,
Specificity, Positive predictive value and negative predictive value of random and
2-hour samples were calculated.
Results: Pearson’s correlation coefficient between 2 and 24 sample was 0.59
(P<0.0001). 2-hour sample predicted significant proteinuria with a sensitivity of
78%, specificity of 66%, and positive value of 64% and negative predictive value
of 80%. Random sample predicted significant proteinuria with a sensitivity of
78%, specificity of 77%, and positive predictive value of 73% and negative
predictive value of 82%. All patients with proteinuria in random and 2-hour
samples had significant proteinuria in 24-hour sample. Only one patient without
proteinuria in random and 2-hour samples had significant proteinuria in 24-hour
sample.
Conclusion: There was a moderate correlation between the 2-hour and the 24-
hour urine protein levels. When the results of 2-hour and random urine samples
are either positive or negative for proteinuria, It is highly valuable for
documentation or ruling out of significant proteinuria.

Keywords

Proteinuria – Pre–Eclampsia - Pregnancy

© 2005, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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