Probing with adjunctive Mitomycin-C in adult patients with nasolacrimal duct obstruction


Mohammadreza Razeghinejad 1 , * , Sayed Ali Banihashemi 2 , Babak Bagheri 3

1 Assistant Professor, Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Assistant Professor, Department of Ophthalmology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Ophthalmologist.

How to Cite: Razeghinejad M, Banihashemi S A, Bagheri B. Probing with adjunctive Mitomycin-C in adult patients with nasolacrimal duct obstruction, Hormozgan Med J. 2005 ; 9(3):e90544.


Hormozgan Medical Journal: 9 (3); e90544
Published Online: February 14, 2006
Article Type: Letter
Received: January 31, 2005
Accepted: February 14, 2006




To evaluate the efficacy of Mitomycin-C during lacrimal probing for adults with
blocked nasolacrimal duct, This prospective, non-comparative, interventional
case series was conducted on 19 eyes of 16 patients from October 2001 to
November 2004 with epiphora caused by nasolacrimal duct obstruction.
The probing was not successful in 2 of the eyes due to proximal bony obstruction
of nasolacrimal duct, so data of 17 eyes of 16 patients were analyzed. Ten
(71.5%) of the patients were female and 4 (28.5%) male. Mean age and standard
deviation of age, duration of epiphora before operation and follow-up period
were 42.1±17.4 years, 2.04±1.03 years and 13.8±8.3 months, respectively.
Bilateral involvement was seen in 3 of the patients. In 6 (35.2%) eyes second
probing with adjunctive Mitomycin-C was done and only in one of them (16.6%)
relative success resulted. In 4 (23.5%) patients immediately after probing
hemorrhage from punctum occurred and stopped spontaneously. No, mild,
moderate and severe watering were seen at the final visit in 4 (23.6%),
2(11.7%), 3(17.7%) and 8(47%) eyes, respectively. Overall in 4 (23.6%) eyes
watering was completely absent and in 9 (53%) eyes watering decreased.
Dacryocystitis occurred in 1 (5.8%) eye after operation and 5 (29.5%) of them
underwent dacryocystrohinostomy owing to sever ephiohora unresponsive to
probing with adjunctive Mitomycin-C.
Conclusion: Complete success after probing with adjunctive Mitomycin-C is not
high, but this procedure is simple, safe and doesn’t need especial equipment. So
it can be considered as an alternative operation in the patient for whom
dacryocystorhinostomy can not be done.


Mitomycins – Lacrimal Duct Obstruction – Adult

© 2005, Hormozgan Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.



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